Structure, biologic properties, and expression of surfactant protein D (SP-D)
نویسندگان
چکیده
منابع مشابه
Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense.
SP-A and SP-D contribute to host defense against respiratory viral infection. The most extensive body of evidence relates to influenza A viruses (IAV), and evidence from gene-deleted mice also indicate a role for surfactant collectins in defense against respiratory syncytial virus (RSV) and adenovirus. Some important respiratory pathogens including rhinovirus and metapneumovirus have not yet be...
متن کاملEvidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.
We tested the hypothesis that pulmonary surfactant-associated lectins--surfactant proteins A and D (SP-A, and -D)--contribute to initial protective mechanisms against influenza A viruses (IAVs). SP-D potently inhibited hemagglutination activity of several strains of IAV as well as causing viral aggregation. SP-D enhanced neutrophil binding of IAV and neutrophil respiratory burst responses to th...
متن کاملCommon Genetic Variants of Surfactant Protein-D (SP-D) Are Associated with Type 2 Diabetes
CONTEXT Surfactant protein-D (SP-D) is a primordial component of the innate immune system intrinsically linked to metabolic pathways. We aimed to study the association of single nucleotide polymorphisms (SNPs) affecting SP-D with insulin resistance and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We evaluated a common genetic variant located in the SP-D coding region (rs721917, Met(31)T...
متن کاملCoccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D
BACKGROUND Coccidioidomycosis or Valley Fever is caused by Coccidioides in Southwest US and Central America. Primary pulmonary infection is initiated by inhalation of air-borne arthroconidia. Since, lung is the first organ that encounters arthroconidia, different components of the pulmonary innate immune system may be involved in the regulation of host defense. Pulmonary surfactant proteins (SP...
متن کاملSurfactant protein-D and pulmonary host defense
Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells, but is also expressed by epithelial cells lining various exocrine ducts and the mucosa of the gastrointestinal and genitourinary tracts...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1998
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(98)00073-8